Apixabano

apixabano

What is apixaban (apixaban)?

Apixaban is a type of medicine known as an anticoagulant - or blood thinner. It makes your blood flow through your veins more easily. This means your blood will be less likely to make a dangerous blood clot. Its used to treat people who have had a health problem caused by a blood clot such as:

How long do you have to take apixaban?

If you have had a blood clot (DVT or pulmonary embolism), youll normally take apixaban for at least 3 months. Depending on what caused the blood clot, you might need to take it for longer. If you have atrial fibrillation, you might need to take apixaban long term or even for the rest of your life.

What is the half life of apixaban?

Apixaban has a total clearance of about 3.3 L/h and a half-life of approximately 12 hours. O-demethylation and hydroxylation at the 3-oxopiperidinyl moiety are the major sites of biotransformation. Apixaban is metabolised mainly via CYP3A4/5 with minor contributions from CYP1A2, 2C8, 2C9, 2C19, and 2J2.

What is the antidote for apixaban?

Andexanet alfa is an FDA approved antidote for apixaban in people with uncontrolled and life-threatening bleeding events.

What is apixaban and how does it work?

What is apixaban? Apixaban is used to lower the risk of stroke caused by a blood clot in people with a heart rhythm disorder called atrial fibrillation. Apixaban is also used after hip or knee replacement surgery to prevent a type of blood clot called deep vein thrombosis (DVT), which can lead to blood clots in the lungs (pulmonary embolism).

Is there a generic version of apixaban?

Apixaban is available as the brand-name drug Eliquis. It’s not available as a generic drug. lower your risk of blood clots and stroke if you have atrial fibrillation without an artificial heart valve prevent deep vein thrombosis (blood clot in your legs) or pulmonary embolism (blood clot in your lungs) after hip or knee replacement surgery

Can apixaban cause blood clots?

This can lead to blood clots forming, which can travel to other parts of your body (such as the lungs or legs) or increase your risk for stroke. In the United States, apixaban is also approved to treat certain types of blood clots ( deep vein thrombosis - DVT, pulmonary embolus-PE) and to prevent them from forming again.

How many mg of apixaban is in Eliquis?

It’s available in two strengths: 2.5 milligrams (mg) and 5 mg. Eliquis contains the active drug apixaban. Is Eliquis a blood thinner? Yes, Eliquis is a blood thinner. It’s also called an anticoagulant.

How long does apixaban stay in your system?

The half-life of Apixaban is 5-6 hour normally but a patient on repeated dosing will show an apparent half-life of 12 hours.? Eliquis is highly protein bound (87%) and NOT dialyzable.

What is the absolute oral bioavailability of apixaban?

The absolute oral bioavailability of apixaban is ~ 50%. Food does not have a clinically meaningful impact on the bioavailability. Apixaban exposure increases dose proportionally for oral doses up to 10 mg. Apixaban is rapidly absorbed, with maximum concentration occurring 3–4 h after oral administration, and has a half-life of approximately 12 h.

What is apixaban (Eliquis)?

Apixaban, sold under the brand name Eliquis, is an anticoagulant medication used to treat and prevent blood clots and to prevent stroke in people with nonvalvular atrial fibrillation through directly inhibiting factor Xa. Specifically it is used to prevent blood clots following hip or knee replacement and in those with a history of prior clots.

What is the half-life of Eliquis?

What is the?half-life of Eliquis? The half-life of Apixaban is 5-6 hour normally but a patient on repeated dosing will show an apparent half-life of 12 hours.? Eliquis is highly protein bound (87%) and NOT dialyzable.

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